[PDF][PDF] Interaction of the antivirus agents remantadine and amantadine with lipid membranes and the influence on the curvature of human red cells
VA Tverdislov, S El-Karadagi, IG Kharitonenkov… - Gen Physiol …, 1986 - gpb.sav.sk
Surface potential difference, conductance, and elasticity changes of bilayer lipid membranes
induced by the antivirus drugs amantadine and remantadine were measured. An influence
on the human erythrocyte shape was shown. Both drugs are stomatocytogenic. The
adsorption at the cytoplasmatic membrane was electrophoretically proved. The heat-
induced vesiculation is partly inhibited. No microvesicles were observed. Instead, large tails
which did not detach from the cell body were seen.
induced by the antivirus drugs amantadine and remantadine were measured. An influence
on the human erythrocyte shape was shown. Both drugs are stomatocytogenic. The
adsorption at the cytoplasmatic membrane was electrophoretically proved. The heat-
induced vesiculation is partly inhibited. No microvesicles were observed. Instead, large tails
which did not detach from the cell body were seen.
